Protein Name cartilage oligomeric matrix protein
Organism Homo sapiens
Gene ID 1311
Gene Symbol

COMP

UniProt P49747 (COMP_HUMAN)
Relationships Total Number of functionally related compound(s) : 72
Total Number of Articles : 70
Description

cartilage oligomeric matrix protein

Gene Summary

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]

synonyms
  • cartilage oligomeric matrix protein
  • cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
  • multiple epiphyseal dysplasia
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Properties