Protein Name angiotensin I converting enzyme
Organism Mus musculus
Gene ID 11421
Gene Symbol

Ace

UniProt P09470 (ACE_MOUSE), Q3TU20 (Q3TU20_MOUSE)
Relationships Total Number of functionally related compound(s) : 298
Total Number of Articles : 415
Description

angiotensin I converting enzyme

Gene Summary

Enables metallocarboxypeptidase activity and peptidyl-dipeptidase activity. Involved in several processes, including angiotensin maturation; cell proliferation in bone marrow; and regulation of gene expression. Acts upstream of or within several processes, including heart contraction; neutrophil mediated immunity; and positive regulation of systemic arterial blood pressure. Located in cytoplasm and plasma membrane. Is active in extracellular region. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); heart valve disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • angiotensin-converting enzyme
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
  • dipeptidyl carboxypeptidase I
Click to show/hide the synonyms
Properties