| Protein Name | membrane metallo endopeptidase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17380 |
| Gene Symbol | Mme |
| UniProt | Q61391 (NEP_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
194
Total Number of Articles : 198 |
Description |
membrane metallo endopeptidase |
| Gene Summary |
Enables metallocarboxypeptidase activity. Involved in several processes, including amyloid-beta clearance; angiotensin maturation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within amyloid-beta metabolic process; limbic system development; and memory. Located in several cellular components, including dendrite; neuron projection terminus; and synaptic vesicle. Is active in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and mammary gland. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |