| Protein Name | flavin containing dimethylaniline monoxygenase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2326 |
| Gene Symbol | FMO1 |
| UniProt | Q01740 (FMO1_HUMAN), A0A024R934 (A0A024R934_HUMAN), B2RCG5 (B2RCG5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
100
Total Number of Articles : 63 |
Description |
flavin containing dimethylaniline monoxygenase 1 |
| Gene Summary |
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
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