| Protein Name | cyclin F |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 899 |
| Gene Symbol | CCNF |
| UniProt | P41002 (CCNF_HUMAN), Q59HD0 (Q59HD0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
17
Total Number of Articles : 12 |
Description |
cyclin F |
| Gene Summary |
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008] |
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