| Protein Name | uracil DNA glycosylase |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7374 |
| Gene Symbol | UNG |
| UniProt | P13051 (UNG_HUMAN), E5KTA6 (E5KTA6_HUMAN), E5KTA5 (E5KTA5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
231
Total Number of Articles : 380 |
Description |
uracil DNA glycosylase |
| Gene Summary |
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010] |
| synonyms |
|
| Properties | |