CPRiL

SNTA1

syntrophin alpha 1

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]

• alpha-1-syntrophin
• 59 kDa dystrophin-associated protein A1 acidic component 1
• acidic alpha 1 syntrophin
dystrophin-associated protein A1, 59kDa, acidic component
pro-TGF-alpha cytoplasmic domain-interacting protein 1
syntrophin-1
LQT12
SNT1
TACIP1
dJ1187J4.5