| Protein Name | MUS81 structure-specific endonuclease subunit |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 80198 |
| Gene Symbol | MUS81 |
| UniProt | Q96NY9 (MUS81_HUMAN), Q53ES5 (Q53ES5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
37
Total Number of Articles : 39 |
Description |
MUS81 structure-specific endonuclease subunit |
| Gene Summary |
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017] |
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| Properties | |