Protein Name serine/threonine kinase 39
Organism Mus musculus
Gene ID 53416
Gene Symbol

Stk39

UniProt Q9Z1W9 (STK39_MOUSE), A2AQL0 (A2AQL0_MOUSE)
Relationships Total Number of functionally related compound(s) : 57
Total Number of Articles : 66
Description

serine/threonine kinase 39

Gene Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including intracellular chloride ion homeostasis; negative regulation of transport; and protein phosphorylation. Acts upstream of or within monoatomic ion homeostasis; regulation of blood pressure; and regulation of inflammatory response. Located in basolateral plasma membrane. Is active in apical plasma membrane and cell body. Is expressed in brain and metanephros. Used to study Gitelman syndrome and pseudohypoaldosteronism. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • STE20/SPS1-related proline-alanine-rich protein kinase
  • Ste-20 related kinase
  • kidney-specific SPAK
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Properties