| Protein Name | actinin alpha 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 87 |
| Gene Symbol | ACTN1 |
| UniProt | P12814 (ACTN1_HUMAN), A0A024R694 (A0A024R694_HUMAN), A0A7I2V4Y4 (A0A7I2V4Y4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
171
Total Number of Articles : 206 |
Description |
actinin alpha 1 |
| Gene Summary |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |