| Protein Name | lymphotoxin beta |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4050 |
| Gene Symbol | LTB |
| UniProt | Q06643 (TNFC_HUMAN), Q5STB2 (Q5STB2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
74
Total Number of Articles : 52 |
Description |
lymphotoxin beta |
| Gene Summary |
Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |