Protein Name UL16 binding protein 2
Organism Homo sapiens
Gene ID 80328
Gene Symbol

ULBP2

UniProt Q9BZM5 (ULBP2_HUMAN)
Relationships Total Number of functionally related compound(s) : 47
Total Number of Articles : 40
Description

UL16 binding protein 2

Gene Summary

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

synonyms
  • UL16-binding protein 2
  • NKG2D ligand 2
  • retinoic acid early transcript 1H
Click to show/hide the synonyms
Properties