Protein Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Organism Mus musculus
Gene ID 270685
Gene Symbol

Mthfd1l

UniProt Q3V3R1 (C1TM_MOUSE)
Relationships Total Number of functionally related compound(s) : 13
Total Number of Articles : 7
Description

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Gene Summary

Enables formate-tetrahydrofolate ligase activity. Involved in chordate embryonic development; formate biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; genitourinary system; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human MTHFD1L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • monofunctional C1-tetrahydrofolate synthase, mitochondrial
  • formyltetrahydrofolate synthetase domain containing 1
  • 2410004L15Rik
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Properties