Protein Name Kruppel-like transcription factor 4 (gut)
Organism Mus musculus
Gene ID 16600
Gene Symbol

Klf4

UniProt Q60793 (KLF4_MOUSE), F2YID5 (F2YID5_MOUSE)
Relationships Total Number of functionally related compound(s) : 149
Total Number of Articles : 170
Description

Kruppel-like transcription factor 4 (gut)

Gene Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Involved in several processes, including canonical Wnt signaling pathway; establishment of skin barrier; and fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and regulation of blastocyst development. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (KLF transcription factor 4). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • Krueppel-like factor 4
  • Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)
  • Kruppel-like factor 4 (gut)
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Properties