| Protein Name | methylenetetrahydrofolate reductase |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17769 |
| Gene Symbol | Mthfr |
| UniProt | Q9WU20 (MTHR_MOUSE), A2A7F7 (A2A7F7_MOUSE), Q3UDB2 (Q3UDB2_MOUSE), Q497H7 (Q497H7_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
73
Total Number of Articles : 88 |
Description |
methylenetetrahydrofolate reductase |
| Gene Summary |
Enables methylenetetrahydrofolate reductase (NADPH) activity. Involved in tetrahydrofolate interconversion. Acts upstream of or within methionine biosynthetic process. Is active in cytosol. Is expressed in several structures, including central nervous system; cranium; heart; sensory organ; and testis. Used to study neural tube defect. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); kidney failure (multiple); and liver disease (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |