| Protein Name | calcium-sensing receptor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24247 |
| Gene Symbol | Casr |
| UniProt | P48442 (CASR_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
166
Total Number of Articles : 191 |
Description |
calcium-sensing receptor |
| Gene Summary |
Enables integrin binding activity; protein kinase binding activity; and transmembrane transporter binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; blood vessel diameter maintenance; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is active in presynaptic membrane. Used to study cardiomyopathy. Biomarker of atherosclerosis; myocardial infarction; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); intellectual disability; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |