| Protein Name | aldo-keto reductase family 1 member C3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8644 |
| Gene Symbol | AKR1C3 |
| UniProt | P42330 (AK1C3_HUMAN), A0A0A0MSS8 (A0A0A0MSS8_HUMAN), B4DKT3 (B4DKT3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
408
Total Number of Articles : 373 |
Description |
aldo-keto reductase family 1 member C3 |
| Gene Summary |
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
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