| Protein Name | histone deacetylase 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 15182 |
| Gene Symbol | Hdac2 |
| UniProt | P70288 (HDAC2_MOUSE), A0A0R4J008 (A0A0R4J008_MOUSE), Q3TMT1 (Q3TMT1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
125
Total Number of Articles : 134 |
Description |
histone deacetylase 2 |
| Gene Summary |
Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including circadian regulation of gene expression; eyelid development in camera-type eye; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to trichostatin A; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, May 2025] |
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