| Protein Name | dual specificity phosphatase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 114856 |
| Gene Symbol | Dusp1 |
| UniProt | Q64623 (DUS1_RAT), Q63683 (Q63683_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
147
Total Number of Articles : 141 |
Description |
dual specificity phosphatase 1 |
| Gene Summary |
Enables growth factor binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and response to hydrogen peroxide. Predicted to be active in cytoplasm and nucleus. Used to study Huntington's disease. Biomarker of several diseases, including autoimmune disease (multiple); diabetic encephalopathy; pancreatitis; portal hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1). [provided by Alliance of Genome Resources, May 2025] |
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