CPRiL

KLRC1

killer cell lectin like receptor C1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]

• NKG2-A/NKG2-B type II integral membrane protein
• C-lectin type II protein
• CD159 antigen-like family member A
NK cell receptor A
NKG2-1/B activating NK receptor
NKG2-A/B type II integral membrane protein
NKG2-A/B-activating NK receptor
killer cell lectin-like receptor subfamily C, member 1
natural killer cell lectin
natural killer group protein 2
CD159A
NKG2
NKG2A