| Protein Name | glutamate decarboxylase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24379 |
| Gene Symbol | Gad1 |
| UniProt | P18088 (DCE1_RAT), C9E895 (C9E895_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
137
Total Number of Articles : 253 |
Description |
glutamate decarboxylase 1 |
| Gene Summary |
Enables glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Involved in several processes, including cellular response to serotonin; gamma-aminobutyric acid biosynthetic process; and positive regulation of locomotion involved in locomotory behavior. Located in neuronal cell body and presynaptic active zone. Used to study diabetes mellitus. Biomarker of several diseases, including autism spectrum disorder; drug psychosis; morphine dependence; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; drug psychosis; and heroin dependence. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |