CPRiL

Protein Name	RNA polymerase II subunit A
Organism	Homo sapiens
Gene ID	5430
Gene Symbol	POLR2A
UniProt	P24928 (RPB1_HUMAN)
Relationships	Total Number of functionally related compound(s) : 40 Total Number of Articles : 45
Description	RNA polymerase II subunit A
Gene Summary	This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
synonyms	DNA-directed RNA polymerase II subunit RPB1 3'-5' exoribonuclease DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit DNA-directed RNA polymerase II subunit A DNA-directed RNA polymerase III largest subunit RNA polymerase II subunit B1 RNA-directed RNA polymerase II subunit RPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa polymerase (RNA) II subunit A NEDHIB POLR2 POLRA RPB1 RPBh1 RPO2 RPOL2 RpIILS hRPB220 hsRPB1 Click to show/hide the synonyms
Properties