CPRiL

MBD4

methyl-CpG binding domain 4, DNA glycosylase

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

• methyl-CpG-binding domain protein 4
• 3,N(4)-ethenocytosine glycosylase
• G/5-fluorouracil mismatch glycosylase with biphasic kinetics
G/T mismatch glycosylase
G/U mismatch glycosylase
methyl-CpG binding domain protein 4
methyl-CpG-binding endonuclease 1
methyl-CpG-binding protein MBD4
mismatch-specific DNA N-glycosylase
putative methyl-CpG binding protein
MED1
TPDS2
UVM1