| Protein Name | glycogen synthase kinase 3 beta |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 84027 |
| Gene Symbol | Gsk3b |
| UniProt | P18266 (GSK3B_RAT), A0A0G2JSH4 (A0A0G2JSH4_RAT), A0A0G2KB98 (A0A0G2KB98_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
622
Total Number of Articles : 1010 |
Description |
glycogen synthase kinase 3 beta |
| Gene Summary |
Enables several functions, including ATP binding activity; protein serine/threonine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neuron projection development; and regulation of synapse organization. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, May 2025] |
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