| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 11096 |
| Gene Symbol | ADAMTS5 |
| UniProt | Q9UNA0 (ATS5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
145
Total Number of Articles : 133 |
Description |
ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| Gene Summary |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
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| Properties | |