CPRiL

Kras

KRAS proto-oncogene, GTPase

Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including cardiac muscle cell proliferation; positive regulation of NF-kappaB transcription factor activity; and response to corticosteroid. Predicted to be located in cytoplasm and cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Biomarker of muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, May 2025]

• GTPase KRas
• K-Ras 2
• Kirsten rat sarcoma viral oncogene homolog
Kirsten rat sarcoma viral oncogene homologue 2 (active)
c-K-ras
c-K-ras2 protein
c-Kirsten-ras proto-oncogene
ki-Ras
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
K-ras
Kras2
c-Ki-ras
p21