| Protein Name | ATP-binding cassette, sub-family B member 1B |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24646 |
| Gene Symbol | Abcb1b |
| UniProt | Q8R427 (Q8R427_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
765
Total Number of Articles : 1099 |
Description |
ATP-binding cassette, sub-family B member 1B |
| Gene Summary |
Predicted to enable ATPase-coupled transmembrane transporter activity; phosphatidylcholine floppase activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; cellular response to external biotic stimulus; and establishment of endothelial blood-brain barrier. Located in Golgi membrane and external side of apical plasma membrane. Used to study colorectal adenocarcinoma; end stage renal disease; epilepsy (multiple); high grade glioma; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; metabolic dysfunction-associated steatotic liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, May 2025] |
| synonyms |
|
| Properties | |