Protein Name neurotrophic receptor tyrosine kinase 2
Organism Homo sapiens
Gene ID 4915
Gene Symbol

NTRK2

UniProt Q16620 (NTRK2_HUMAN), A0A024R230 (A0A024R230_HUMAN), Q5VWE5 (Q5VWE5_HUMAN), Q548C2 (Q548C2_HUMAN)
Relationships Total Number of functionally related compound(s) : 341
Total Number of Articles : 483
Description

neurotrophic receptor tyrosine kinase 2

Gene Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

synonyms
  • BDNF/NT-3 growth factors receptor
  • BDNF-tropomyosine receptor kinase B
  • neurotrophic tyrosine kinase receptor type 2
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Properties