| Protein Name | cytochrome P450, family 2, subfamily e, polypeptide 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25086 |
| Gene Symbol | Cyp2e1 |
| UniProt | P05182 (CP2E1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
709
Total Number of Articles : 921 |
Description |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
| Gene Summary |
Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to 3-methylcholanthrene; response to ethanol; and response to ozone. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Used to study alcohol dependence and drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; liver disease (multiple); middle cerebral artery infarction; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in acoustic neuroma; gastrointestinal system cancer (multiple); high grade glioma; liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, May 2025] |
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