| Protein Name | hypoxia inducible factor 1 subunit alpha |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 29560 |
| Gene Symbol | Hif1a |
| UniProt | O35800 (HIF1A_RAT), D4A8P8 (D4A8P8_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
661
Total Number of Articles : 1064 |
Description |
hypoxia inducible factor 1 subunit alpha |
| Gene Summary |
Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to decreased oxygen levels; positive regulation of angiogenesis; and regulation of biosynthetic process. Located in nucleus. Used to study acute kidney failure; cerebrovascular disease (multiple); diabetic retinopathy; and hepatocellular carcinoma. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; bronchopulmonary dysplasia; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha). [provided by Alliance of Genome Resources, May 2025] |
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