| Protein Name | sirtuin 3 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 293615 |
| Gene Symbol | Sirt3 |
| UniProt | B2RZ31 (B2RZ31_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
154
Total Number of Articles : 191 |
Description |
sirtuin 3 |
| Gene Summary |
Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |