Protein Name activating transcription factor 4
Organism Rattus norvegicus
Gene ID 79255
Gene Symbol

Atf4

UniProt Q9ES19 (ATF4_RAT), B0BMW3 (B0BMW3_RAT)
Relationships Total Number of functionally related compound(s) : 138
Total Number of Articles : 150
Description

activating transcription factor 4

Gene Summary

Enables DNA-binding transcription factor binding activity and general transcription initiation factor binding activity. Involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and response to manganese-induced endoplasmic reticulum stress. Located in dendrite membrane. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • cyclic AMP-dependent transcription factor ATF-4
  • activating transcription factor 4 (tax-responsive enhancer element B67)
  • activating transcription factor ATF-4
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Properties