| Protein Name | OTU deubiquitinase 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 55593 |
| Gene Symbol | OTUD5 |
| UniProt | Q96G74 (OTUD5_HUMAN), A0A024QZ09 (A0A024QZ09_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
16
Total Number of Articles : 13 |
Description |
OTU deubiquitinase 5 |
| Gene Summary |
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008] |
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