| Protein Name | uncoupling protein 2 (mitochondrial, proton carrier) |
|---|---|
| Organism | Mus musculus |
| Gene ID | 22228 |
| Gene Symbol | Ucp2 |
| UniProt | P70406 (UCP2_MOUSE), Q549J5 (Q549J5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
211
Total Number of Articles : 294 |
Description |
uncoupling protein 2 (mitochondrial, proton carrier) |
| Gene Summary |
Enables GDP binding activity. Involved in several processes, including cellular response to glucose stimulus; macrophage differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cerebral cortex; hemolymphoid system; integumental system; and nose. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, May 2025] |
| synonyms |
|
| Properties | |