| Protein Name | FAT atypical cadherin 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 14107 |
| Gene Symbol | Fat1 |
| UniProt | F2Z4A3 (F2Z4A3_MOUSE), A0A087WRT4 (A0A087WRT4_MOUSE), A0A1L1SQU7 (A0A1L1SQU7_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
137
Total Number of Articles : 171 |
Description |
FAT atypical cadherin 1 |
| Gene Summary |
Involved in epithelial cell morphogenesis; establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis; and lens development in camera-type eye. Acts upstream of or within actin filament organization; cell-cell adhesion; and establishment or maintenance of cell polarity. Located in cell junction; filopodium; and lamellipodium. Is active in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study facioscapulohumeral muscular dystrophy and nephrotic syndrome. Human ortholog(s) of this gene implicated in colorectal cancer; esophagus squamous cell carcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and oral squamous cell carcinoma. Orthologous to human FAT1 (FAT atypical cadherin 1). [provided by Alliance of Genome Resources, May 2025] |
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