| Protein Name | X-ray repair cross complementing 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7517 |
| Gene Symbol | XRCC3 |
| UniProt | O43542 (XRCC3_HUMAN), Q53XC8 (Q53XC8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
74
Total Number of Articles : 119 |
Description |
X-ray repair cross complementing 3 |
| Gene Summary |
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
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