| Protein Name | BZIP domain-containing protein;Protein skinhead-1 |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 177343 |
| Gene Symbol | skn-1 |
| UniProt | P34707 (SKN1_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
133
Total Number of Articles : 151 |
Description |
BZIP domain-containing protein;Protein skinhead-1 |
| Gene Summary |
Enables Hsp70 protein binding activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; endoplasmic reticulum unfolded protein response; and positive regulation of macromolecule biosynthetic process. Located in endoplasmic reticulum; mitochondrion; and nucleus. Is expressed in several structures, including AB; C; germ line; head ganglion; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to several human genes including NFE2L1 (NFE2 like bZIP transcription factor 1); NFE2L2 (NFE2 like bZIP transcription factor 2); and NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, May 2025] |
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