| Protein Name | vasodilator stimulated phosphoprotein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 7408 |
| Gene Symbol | VASP |
| UniProt | P50552 (VASP_HUMAN), A0A024R0V4 (A0A024R0V4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
227
Total Number of Articles : 376 |
Description |
vasodilator stimulated phosphoprotein |
| Gene Summary |
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] |
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