| Protein Name | leptin receptor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16847 |
| Gene Symbol | Lepr |
| UniProt | P48356 (LEPR_MOUSE), Q3US58 (Q3US58_MOUSE), Q3UNU8 (Q3UNU8_MOUSE), Q640Q2 (Q640Q2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
133
Total Number of Articles : 157 |
Description |
leptin receptor |
| Gene Summary |
Enables leptin receptor activity. Involved in several processes, including glucose homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and respiratory system. Used to study metabolic dysfunction-associated steatotic liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |