| Protein Name | IKAROS family zinc finger 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 22806 |
| Gene Symbol | IKZF3 |
| UniProt | Q9UKT9 (IKZF3_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
39
Total Number of Articles : 74 |
Description |
IKAROS family zinc finger 3 |
| Gene Summary |
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] |
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| Properties | |