| Protein Name | Janus kinase 3 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16453 |
| Gene Symbol | Jak3 |
| UniProt | Q62137 (JAK3_MOUSE), A0A0R4J0R7 (A0A0R4J0R7_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
98
Total Number of Articles : 111 |
Description |
Janus kinase 3 |
| Gene Summary |
Enables protein tyrosine kinase activity. Involved in several processes, including negative regulation of T-helper 1 cell differentiation; negative regulation of macromolecule biosynthetic process; and regulation of apoptotic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; peptidyl-tyrosine phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoskeleton; endomembrane system; and membrane. Predicted to be active in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study severe combined immunodeficiency 104. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe combined immunodeficiency. Orthologous to human JAK3 (Janus kinase 3). [provided by Alliance of Genome Resources, May 2025] |
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