Protein Name FMS-like tyrosine kinase 1
Organism Mus musculus
Gene ID 14254
Gene Symbol

Flt1

UniProt P35969 (VGFR1_MOUSE), A0A0R4J0A4 (A0A0R4J0A4_MOUSE)
Relationships Total Number of functionally related compound(s) : 180
Total Number of Articles : 185
Description

FMS-like tyrosine kinase 1

Gene Summary

Enables identical protein binding activity and vascular endothelial growth factor receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; bronchopulmonary dysplasia; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • vascular endothelial growth factor receptor 1
  • embryonic receptor kinase 2
  • tyrosine-protein kinase receptor FLT
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Properties