| Protein Name | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18035 |
| Gene Symbol | Nfkbia |
| UniProt | Q9Z1E3 (IKBA_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
734
Total Number of Articles : 956 |
Description |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
| Gene Summary |
Enables transcription regulator inhibitor activity. Involved in B cell receptor signaling pathway; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of transcription initiation by RNA polymerase II. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; negative regulation of Notch signaling pathway; and pattern recognition receptor signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and naris. Used to study Sjogren's syndrome and atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, May 2025] |
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