| Protein Name | bone morphogenetic protein 4 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25296 |
| Gene Symbol | Bmp4 |
| UniProt | Q6AYU9 (Q6AYU9_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
110
Total Number of Articles : 89 |
Description |
bone morphogenetic protein 4 |
| Gene Summary |
Enables growth factor activity and identical protein binding activity. Involved in several processes, including lung development; positive regulation of calcium ion transmembrane transport; and positive regulation of cell differentiation. Acts upstream of or within positive regulation of ossification and positive regulation of transcription by RNA polymerase II. Located in extracellular space and vesicle. Biomarker of Barrett's esophagus; congenital diaphragmatic hernia; epilepsy; peptic esophagitis; and prolactinoma. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and syndromic microphthalmia 6. Orthologous to human BMP4 (bone morphogenetic protein 4). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |