| Protein Name | glutamate ionotropic receptor NMDA type subunit 2B |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24410 |
| Gene Symbol | Grin2b |
| UniProt | Q00960 (NMDE2_RAT), G3V746 (G3V746_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
505
Total Number of Articles : 910 |
Description |
glutamate ionotropic receptor NMDA type subunit 2B |
| Gene Summary |
Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; cannabis abuse; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; cognitive disorder (multiple); heroin dependence; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, May 2025] |
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