| Protein Name | mitogen-activated protein kinase 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 26413 |
| Gene Symbol | Mapk1 |
| UniProt | P63085 (MK01_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
1992
Total Number of Articles : 3693 |
Description |
mitogen-activated protein kinase 1 |
| Gene Summary |
Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; embryonic organ development; and respiratory system development. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, May 2025] |
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