| Protein Name | AKT serine/threonine kinase 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24185 |
| Gene Symbol | Akt1 |
| UniProt | P47196 (AKT1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
2385
Total Number of Articles : 5366 |
Description |
AKT serine/threonine kinase 1 |
| Gene Summary |
Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and enzyme binding activity. Involved in several processes, including cellular hyperosmotic salinity response; protein phosphorylation; and regulation of protein metabolic process. Acts upstream of or within several processes, including negative regulation of cell size; positive regulation of sodium ion transport; and regulation of protein localization. Located in cytosol; dendrite; and nucleus. Used to study artery disease (multiple); autosomal recessive polycystic kidney disease; heroin dependence; impotence; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; liver disease (multiple); opiate dependence; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); gastrointestinal system cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1). [provided by Alliance of Genome Resources, May 2025] |
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