| Protein Name | amyloid beta precursor protein |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 54226 |
| Gene Symbol | App |
| UniProt | P08592 (A4_RAT), Q6P6Q5 (Q6P6Q5_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
871
Total Number of Articles : 1174 |
Description |
amyloid beta precursor protein |
| Gene Summary |
Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to cAMP; cellular response to norepinephrine stimulus; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; alcoholic hepatitis; brain disease (multiple); and iron deficiency anemia. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |