| Protein Name | mediator complex subunit 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5469 |
| Gene Symbol | MED1 |
| UniProt | Q15648 (MED1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
136
Total Number of Articles : 92 |
Description |
mediator complex subunit 1 |
| Gene Summary |
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008] |
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