| Protein Name | Fos proto-oncogene, AP-1 transcription factor subunit |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2353 |
| Gene Symbol | FOS |
| UniProt | P01100 (FOS_HUMAN), Q6FG41 (Q6FG41_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1431
Total Number of Articles : 2823 |
Description |
Fos proto-oncogene, AP-1 transcription factor subunit |
| Gene Summary |
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008] |
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